Startups
Enspire DBS Therapy
Enspire DBS Therapy, Inc. is a Cleveland, Ohio medical-device company developing deep brain stimulation combined with structured rehabilitation for people with chronic upper-extremity impairment after stroke. Cleveland Clinic describes it as a spinout established in2010 to commercialize research by André Machado and Kenneth Baker. Its investigational approach stimulates cerebellar pathways to support rehabilitation and motor recovery. The company sponsors RESTORE, a multicenter pivotal PhaseII/III study, following the small EDEN feasibility study. The device is investigational and limited by United States law to investigational use; clinical studies and preclinical findings do not establish marketing approval or proven benefit for all patients. A January2026 SeriesB1 financing supports continued pivotal-trial enrollment. Publicly identifiable personnel include company staff, directors, scientific researchers and qualified historical advisors; a complete current employee directory is not published.
Team
 Andre G. MachadoChief Medical and Scientific Officer · Board Member |
Christopher PekrulTeam Member |
David A. BlumTeam Member |
Emma Claire Lambert-ShemoResearch Intern (historical) |
Hanah RahroohTeam Member |
 Jaimie HendersonMedical Advisory Board Member |
 Jamie StiffBoard Member |
 Jon David FriedlandBoard Member |
 Kenneth B. BakerBoard Member |
Laurie TothTeam Member |
Mark PierreDirector, Clinical and Regulatory Affairs (historical) |
Mark RaffaTeam Member |
Nikolas KokonesResearch Collaborator (2025–2026 publication) |
Scott KokonesChief Executive Officer |
Vince O.Team Member |
Winifred WuTeam Member |