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Montara Therapeutics

Montara Therapeutics is a San Francisco biotechnology company developing brain-selective medicines for neurological diseases. Its BrainOnly platform combines a brain-penetrant therapeutic with a peripheral blocker intended to limit drug activity outside the brain. The platform derives from UCSF research and an exclusive technology license. Its lead program, MTX-E1, combines the MT1110 peripheral blocker with everolimus for tuberous sclerosis complex-related epilepsy; additional research targets Parkinson's disease and other neurological conditions. As of September 2026, Montara was completing IND-enabling work and preparing for first-in-human studies. Its programs remain investigational. Founder and CEO Nicholas T. Hertz leads the company with Chief Medical Officer David Michelson, Chief Technology Officer Zachary Hill and Chief Business Officer Dirk Landgraf. The company raised an $8 million seed round in July 2024 and a $20 million seed expansion in March 2025, totaling $28 million in seed financing. The Michael J. Fox Foundation subsequently supported separate LRRK2 and mTOR Parkinson's research projects with non-dilutive grants.

Founded 2023

Team

Andrew MillerAndrew MillerBoard Member
David MichelsonDavid MichelsonChief Medical Officer
Dirk LandgrafDirk LandgrafChief Business Officer
Eric KarranEric KarranNeuroscience Advisor
J. Seth StrattanJ. Seth StrattanBoard Member
Jacqueline FrenchJacqueline FrenchClinical Advisor
James SummersJames SummersNeuroscience Advisor
Jenna AronsonJenna AronsonBoard Observer
John BurkhardtJohn BurkhardtToxicology Advisor
Joseph ArenaJoseph ArenaRegulatory Affairs Advisor
Kevan ShokatKevan ShokatCo-Scientific Founder & Chairman of the SAB
Martin KampmannMartin KampmannCo-Scientific Founder & SAB Member
Max LebovitzMax LebovitzVice President, Business Operations
Michael KeiserMichael KeiserSAB Member
Miles GersonMiles GersonBoard Member
Miratul MuqitMiratul MuqitSAB Member
Nicholas T. HertzNicholas T. HertzFounder, President and Chief Executive Officer · Board Member
Rishi RakhitRishi RakhitVice President, Pharmacology
Shawn JohnstoneShawn JohnstoneSynthetic Chemistry Advisor
Stevan DjuricStevan DjuricMedicinal Chemistry Advisor
Thomas SudhofScientific Co-Founder
Troy WilsonTroy WilsonChair of the Board
Zachary HillZachary HillChief Technology Officer
Ziyang ZhangZiyang ZhangSAB Member

Investments