Glycomine is a clinical-stage biotechnology company developing replacement therapies for serious rare genetic diseases. Its platform delivers substrates, enzymes or proteins into relevant cells to bypass disrupted biochemical pathways. Its lead investigational medicine, GLM101, delivers mannose-1-phosphate to address the metabolic defect in PMM2-congenital disorder of glycosylation, a multisystem disease with neurological symptoms including ataxia. The company completed enrollment in its global randomized Phase 2b POLAR study in April 2026. Glycomine is based in San Carlos, California.