Entities

Baltimore medical technology company, formerly Semaphor Surgical, building AI and simulation infrastructure for procedural devices. Uses virtual patients grounded in clinical and procedural data to help manufacturers design, test and validate devices, including implants, heart valves and surgical robots. Its founders combine neurosurgery, computer vision and autonomous robotics expertise at Johns Hopkins.

Develops AI endpoints that help pharmaceutical companies evaluate cancer treatments in clinical trials. Its IPRO model analyzes routine radiology scans to predict survival outcomes and identify treatment effects earlier, using models trained on longitudinal imaging, molecular, clinical and outcomes data. The platform supports analysis of Phase 1–4 oncology trials.

Coolant develops spatial AI and 3D computer vision tools for forestry, land management and carbon measurement. Its 3D Forest Vision platform reconstructs digital twins from aerial drone photographs to measure individual trees, assess timber inventory and damage, and estimate biomass and carbon. Founded in 2023, Coolant Climate, Inc. is led by co-founders Michael Wu, Matthew Zane and Belal Shaheen. In October 2025 it announced USD4.3 million in total pre-seed and seed funding, with Floodgate leading the pre-seed and General Catalyst leading the seed. Wicklow Capital and Ponderosa Ventures also participated; individual round amounts were not disclosed.

Provides identity verification, authentication and device-trust infrastructure for consumer applications. Its APIs and SDKs combine silent mobile-network authentication, WhatsApp, passkeys, email and SMS routing with SIM binding and device intelligence to simplify sign-in and reduce fraud.

Reev develops powered knee orthoses that use sensors and AI to assist walking for people with neurological gait disorders.