Criticality is an early-stage venture investment brand backing founders working on technically difficult problems with urgent practical applications. It invests at seed and Series A in deep technology, foundational infrastructure and overlooked or underserved systems, with disclosed portfolio areas including AI for drug discovery and clinical trials, healthcare delivery, advanced housing construction and other physical-world technologies. Its current published portfolio includes OM Therapeutics, Karoo Health, Standard Electron, Orion Sleep, Cedar, Vital Care, Dream and The American Housing Corporation. The strategy combines long-term technical conviction with support for scaling companies and institutional partnerships. Criticality builds on Antler’s US platform and complements its pre-seed investing, while its launch announcement describes the fund as independently managed. Its first fund is anchored by the New Mexico State Investment Council, aligning commercial investment returns with regional development and broader economic resilience.
Founded
2025
Type
Venture capital
Funds1
Criticality Fund I LP$65M
Criticality Fund I LP is a Delaware venture capital fund investing at seed and Series A in deep technology and underserved sectors. Its investment areas include AI applications in drug discovery and clinical trials, foundational infrastructure, modular housing and healthcare delivery. Anchored by the New Mexico State Investment Council, the fund was publicly announced as fully closed at USD65 million and actively deploying capital in July 2025. Its registered general partner is Antler New Mexico General Partner LLC; it is reported in the Form ADV of Antler Innovation US LLC.
