Startups
Applied Cognition
Redwood City, California, United States
Applied Cognition Inc. is a private neuroscience and biomedical technology company in Redwood City, California developing noninvasive measurement of human glymphatic function and investigational treatments directed at brain waste clearance. Its sensor and research platform measures physiological features associated with sleep-active clearance of amyloid beta, tau and other metabolites. The company combines biomedical engineering, neuroscience, clinical research, algorithms and data science; its published mission includes building a dataset for future AI integration in therapeutic discovery. Its pipeline includes investigational ACX-02 and exploratory ACX-14 programs targeting glymphatic mechanisms relevant to Alzheimer’s disease, Parkinson’s disease and post-traumatic headache. Peer-reviewed human studies and a March 2026 preprint report physiological and biomarker findings; these are not proof of disease prevention or regulatory approval. The current public leadership directory names co-founders Paul Dagum and Jake Winebaum. Additional research affiliations are qualified against dated scientific publications. Primary investor portfolios verify backing from GreyMatter Capital, Mayfield, What If Ventures, Supermoon Capital and A&E Investments; exact company cash financing amounts, stages and closing dates remain undisclosed in reviewed primary sources. An MTEC technology showcase also confirms a government-sponsored research award, with its amount, award date and precise legal sponsor unverified.
Team
 Alejandro CorbelliniCompany-affiliated research author (2026 publications) |
 Jake WinebaumChairman & Co-founder |
 Laurent GiovangrandiSenior Principal Scientist / Engineer |
 Paul DagumCEO & Co-founder |
Tarandeep SinghCompany-affiliated research author (2025–2026 publications) |